请选择 进入手机版 | 继续访问电脑版

知识人论坛

 找回密码
 立即注册
搜索
热搜: 活动 交友 discuz
查看: 389|回复: 0

美国克利夫兰诊所代谢和前列腺癌的分子机制方向博士后

[复制链接]

529

主题

537

帖子

2417

积分

超级版主

Rank: 8Rank: 8

积分
2417
发表于 2016-3-31 09:39:27 | 显示全部楼层 |阅读模式
Metabolic and Molecular Mechanisms of Prostate Cancer
[tr][/tr]
Employer:
Cleveland Clinic
Job Number:
4017916
Date Posted:
03/24/2016
Application Deadline:
Open Until Filled
Job Description
A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology.

Our laboratory is focused on molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. Specific areas include:

1) Metabolic and genetic changes required for androgen synthesis

2) Clinical validation in patients and clinical trials utilizing innovative approaches

3) Animal models of advanced prostate cancer for translational and therapeutic studies

4) Identifying targets for the development of new pharmacologic therapies

We recently discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51). We are currently working toward defining the relationship between metabolite generation and treatment response in patients and identifying new chemical entities that are determinants of treatment response.

We also discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084). We are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. Our work was featured in an “Editor’s Choice” in Science Translational Medicine and a “Research Watch” in Cancer Discovery.

Previously, we discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite. This metabolic pathway occurs in patient tumors (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33).

回复

使用道具 举报

您需要登录后才可以回帖 登录 | 立即注册

本版积分规则

小黑屋|手机版|Archiver|知识人网  

GMT+8, 2017-3-26 01:34 , Processed in 1.122065 second(s), 26 queries .

Powered by Discuz! X3.2

© 2001-2013 Comsenz Inc.

快速回复 返回顶部 返回列表